Pregabalin is the generic product of the brand Lyrica. This is a pain medication pill that helps for many issues listed bellow. It is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.
- Pregabalin is used to treat pain caused by fibromyalgia, or nerve pain in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia), or spinal cord injury.
- Pregabalin is usually taken 2 or 3 times a day. You can take it with or without food.
- You don’t have to have epilepsy for pregabalin to help with pain or anxiety.
- It takes at least a few weeks for pregabalin to work.
- The side effects of pregabalin are usually mild and go away by themselves. The most common ones are feeling sleepy, dizziness and headaches.
- Pregabalin is also called by the brand names Lyrica, Prebel, Pregacon, Nervigesic
Diabetic Peripheral Neuropathic Pain
- Initial: 50 mg orally every 8 hours
- Maintenance: May increase to 100 mg orally every 8 hours within 1 week, as needed; not to exceed 300 mg/day
- Initial: 150-300 mg/day orally divided every 8-12 hours
- Maintenance: May increase to 300 mg/day divided every 8-12 hours after 1 week, as needed
- Adult, Initial: 150 mg/day orally divided every 12 hours
- Adult, Maintenance: May increase to 300-450 mg/day divided every 12 hours after 1 week, as needed
- Pediatric: Safety and efficacy not established
- A 15-week, placebo-controlled trial (n=107) was conducted in pediatric patients with fibromyalgia aged 12-17 years with pregabalin (75-450 mg/day)
- The primary efficacy endpoint of change from baseline to Week 15 in mean pain intensity (derived from an 11-point numeric rating scale) showed numerically greater improvement for the pregabalin-treated patients compared to placebo-treated patients, but did not reach statistical significance
- Initial: 150 mg/day divided every 8-12 hours orally
- Maintenance: May increase to 600 mg/day orally divided every 8-12 hours, as needed
Neuropathic Pain With Spinal Cord Injury
- Initial: 150 mg/day orally divided every 12 hours; may increase within 1 week to 300 mg/day orally divided every 12 hours
- If there is insufficient pain relief after 2-3 weeks and 300 mg/day dose is tolerated, may increase dose again up to 600 mg/day orally divided every 12 hours